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Preventing Neurologic Complications in Valve Surgery

NCT07382362 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2026-02-02

No results posted yet for this study

Summary

In patients with valvular heart disease and atrial fibrillation (AF) undergoing surgical valve surgery, current guidelines recommend concomitant surgical management of the left atrial appendage (LAA) to prevent postoperative thromboembolic events, particularly neurologic embolic events. However, whether concomitant LAA management benefits patients without AF by reducing postoperative neurologic complications remains controversial.

Given these uncertainties, this study aims to evaluate whether concomitant LAA suture closure during surgical valve surgery is associated with a lower incidence of perioperative silent cerebral infarction.

Conditions

  • Left Atrial Appendage Closure

Interventions

PROCEDURE

Left Atrial Appendage (LAA) Suture Closure

Concomitant suture closure of the LAA performed at the time of surgical valve surgery, at the discretion of the operating surgeon.

PROCEDURE

Surgical Valve Surgery

Standard surgical valve repair or replacement performed according to routine clinical practice.

Sponsors & Collaborators

  • China National Center for Cardiovascular Diseases

    lead OTHER_GOV

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-01-27
Primary Completion
2028-01-31
Completion
2028-07-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07382362 on ClinicalTrials.gov