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Cerebral Microembolization Associated With PFO Closure

NCT06347276 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 800

Last updated 2025-07-24

No results posted yet for this study

Summary

This study aims to investigate (1) the de novo cerebral microembolization in patients who undergo transcatheter closure of PFO or ASD, and (2) evaluate the relationship between de novo cerebral microembolization and in situ thrombus within PFO.

Conditions

  • Thrombosis Cardiac
  • Atrial Septal Defect
  • Patent Foramen Ovale (PFO)

Interventions

DEVICE

PFO occluder; ASD occluder

Transcatheter closure of atrial septal defect (ASD) and patent foramen ovale (PFO) All cases will be examined with DW-MRI preoperatively, and DW-MRI will be repeated 24 hours and 4 weeks after the transcatheter closure procedure.

Sponsors & Collaborators

  • Beijing Anzhen Hospital

    collaborator OTHER

  • The Affiliated Hospital of Xuzhou Medical University

    collaborator OTHER

  • Tibet Autonomous Region People's Hospital

    collaborator OTHER

  • Beijing Tiantan Hospital

    collaborator OTHER

  • Xuanwu Hospital, Beijing

    collaborator OTHER

  • China National Center for Cardiovascular Diseases

    lead OTHER_GOV

Principal Investigators

  • Chaowu Yan, PhD MD · Cardiovascular Institute and Fuwai Hospital

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-01-01
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06347276 on ClinicalTrials.gov