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Towards Causal Mapping of Episodic Memory iEEG Networks Via Multi-method Brain Stimulation

NCT07378332 · Status: ENROLLING_BY_INVITATION · Phase: NA · Type: INTERVENTIONAL · Enrollment: 44

Last updated 2026-01-30

No results posted yet for this study

Summary

Human intracranial electroencephalography (EEG) can provide brain-activity correlates of memory with high spatial and temporal resolution. This project will test functional relevance of these neural signals for memory behavioral performance using novel noninvasive and invasive stimulation methods. Findings will advance understanding of brain mechanisms for memory, as is needed to accelerate progress in the treatment of memory disorders.

Conditions

  • Memory Performance
  • Hippocampal Activity

Interventions

OTHER

TMS electrical stimulation parameters during cognitive and memory demands

Study conditions will involve electrical stimulation delivered through non-invasive TMS. These different stimulation parameters will include the presence of stimulation (no stimulation versus stimulation) and the location of stimulation.

OTHER

DES electrical stimulation parameters during cognitive and memory demands

Study conditions will involve direct electrical stimulation delivered through implanted iEEG electrodes. These different stimulation parameters will include the presence of stimulation (no stimulation versus stimulation) and the location of stimulation across the same electrode or a different electrode.

Sponsors & Collaborators

  • Northwestern University, Chicago, IL

    collaborator UNKNOWN

  • Washington University School of Medicine

    collaborator OTHER

  • University of Chicago

    lead OTHER

Principal Investigators

  • Joel Voss, PhD · University of Chicago

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-09-15
Primary Completion
2028-04-30
Completion
2028-06-30

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07378332 on ClinicalTrials.gov