Investigating the Plasticity of Human Predictive Coding Through Neuromodulation

Summary

The hypothesis of the study is to investigate how different trm (tES) methods (transcranial Alternating Current Stimulation, tACS, and transcranial Random Noise Stimulation, tRNS) applied at different stimulation frequencies and networks can modulate the predictive mechanisms in human perception and cognition. This is an interventional, monocentric, cross-sectional randomized, single-blinded study on healthy adult volunteers, recruited through online advertisements, flyers and oral transmission. Volunteers will be recruited from the general population of young adults.

Conditions

• Human Brain and Cognition

Interventions

PROCEDURE

Occipital tACS at IAF-2Hz

tACS applied to occipital areas at 2 Hz below the individual alpha frequency (IAF)

PROCEDURE

Occipital tACS at IAF+2Hz

tACS applied to occipital areas at 2 Hz above the individual alpha frequency (IAF)

PROCEDURE

Frontal tACS at 4-7 Hz

tACS applied to frontal areas at 4-7 Hz

PROCEDURE

Occipital tRNS

tRNS applied to occipital brain regions

PROCEDURE

Frontal tRNS

tRNS applied to frontal brain regions

PROCEDURE

Sham/placebo tACS

tACS is activated only for 30 seconds and then turned off, thus resulting ineffective

PROCEDURE

Sham/placebo tRNS

tRNS is activated only for 30 seconds and then turned off, thus resulting ineffective

Sponsors & Collaborators

• Alessia Santoni

  collaborator UNKNOWN

• Sara Stottmeier

  collaborator UNKNOWN

• Klara Hemmerich

  collaborator UNKNOWN

• Giuseppe Di Dona

  collaborator UNKNOWN

• Luigi Ferini-Strambi

  collaborator UNKNOWN

• Università Vita-Salute San Raffaele

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

35 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2024-06-13

Primary Completion

2026-04-30

Completion

2026-12-31

Countries

• Italy

Study Locations