Women's Heart: Impact of Ultra-endurance and Hormonal Profile on Cardiac and Systemic Inflammatory Parameters in Female Runners

Summary

The goal of this clinical trial is to describe the cardiac and systemic inflammatory adaptations specific to women practicing ultra-endurance sports.

The objectives are to:

* Improve the understanding of cardiac and systemic inflammatory adaptations specific to women participating in ultra-endurance sports.
* Assess the relationship between observed cardiac and systemic inflammatory alterations and the relative levels of estrogen, testosterone, and progesterone.
* Describe the vascular adaptations specific to women participating in ultra-endurance sports.
* Examine the influence of defense mechanisms on the emotional dynamics observed during and after an ultra-endurance race.

Conditions

• Healthy Volunteer

Interventions

PROCEDURE

Echocardiography

6 transthoracic echocardiography will be performed: 1 before the race, 3 during the race (refreshment station), 1 at the end of the race, 1 at the follow up visit 9 days after the race. It is not possible to specify the intervention time, as this depends on the participants' running pace.

PROCEDURE

Arterial ultrasound

6 ultrasound of the carotid and femoral arteries will be performed: 1 before the race, 3 during the race (refreshment station), 1 at the end of the race, 1 at the follow up visit 9 days after the race. It is not possible to specify the intervention time, as this depends on the participants' running pace.

BIOLOGICAL

Blood sampling

6 blood sampling (2 milliliters) will be performed: 1 before the race, 3 during the race (refreshment station), 1 at the end of the race, 1 at the follow up visit 9 days after the race. It is not possible to specify the intervention time, as this depends on the participants' running pace.

BEHAVIORAL

Scales and questionnaire

Before the race, during the race (refreshment station), and at the end of the race participant will be asked to complete the study questionnaire and scales. It is not possible to specify the intervention time, as this depends on the participants' running pace.

PROCEDURE

Vital signs

6 measurements of blood pressure, heart rate, respiratory rate, pulse oxygen saturation, and muscle oxygen saturation will then be taken: 1 before the race, 3 during the race (refreshment station), 1 at the end of the race, 1 at the follow up visit 9 days after the race. It is not possible to specify the intervention time, as this depends on the participants' running pace.

BIOLOGICAL

Urinary test

Pregnancy test will be performed before the race.

Sponsors & Collaborators

• French Cardiology Society

  lead OTHER

Principal Investigators

• Romain JOUFFROY, MD · CHU d'Orléans

Study Design

Allocation

NA

Purpose

OTHER

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2026-03-22

Primary Completion

2026-09-30

Completion

2026-09-30

Countries

• France

Study Locations