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Macrophage/Monocyte Driven Inflammation and Anesthetic Sensitivity in Aging

NCT07372417 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2026-01-28

No results posted yet for this study

Summary

The goal of this observational study is to determine whether macrophage/monocyte mediated inflammatory signaling contributes to reduced anesthetic requirements in older adults undergoing major abdominal surgery. The main questions it aims to answer are:

* Is there a difference in anesthetic dosing requirements (minimum effective dose) between young and older patients undergoing major abdominal surgery?
* How do electroencephalographic (EEG) signatures under anesthesia correlate with age and systemic inflammatory markers?
* Is there an association between age, levels of circulating inflammatory cytokines, and monocyte/macrophage phenotypes with anesthetic requirements?

If there is a comparison group: Researchers will compare older adult patients undergoing major abdominal surgery to younger adult patients undergoing major abdominal surgery to see if macrophage/monocyte-mediated inflammatory signaling influences anesthetic sensitivity and the risk of postoperative neurocognitive complications in the older population.

Participants will:

* Receive general anesthesia for major abdominal surgery, with continuous recording of anesthetic dose requirements.
* Undergo electroencephalographic (EEG) monitoring during the anesthetic period.
* Provide blood samples for the measurement of circulating inflammatory cytokines and the assessment of monocyte phenotypes.
* Provide peritoneal tissue samples (collected during surgery) to evaluate tissue macrophage populations.
* Provide cerebrospinal fluid (CSF) samples to assess biomarkers of blood-brain barrier permeability.

Conditions

  • Aging
  • Inflammation
  • Blood-Brain Barrier Permeability
  • Anesthesia Brain Monitor
  • Anesthesia Depth Monitoring
  • Inflammation Biomarkers
  • Inflammaging
  • Monocyte

Sponsors & Collaborators

  • University of Chile

    lead OTHER

Principal Investigators

  • Antonello Penna Silva, Anesthesia Professor, MD PhD · Brain and Anesthesia Laboratory (BAL), University of Chile

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-01-25
Primary Completion
2027-04-15
Completion
2027-06-15

Countries

  • Chile

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07372417 on ClinicalTrials.gov