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Anesthetic Depth Effects Upon Immune Competent Cells

NCT02794896 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 16

Last updated 2022-05-24

No results posted yet for this study

Summary

Anesthesia depth affects the proliferation of lymphocytes to NK-cells and memory T-cells effect and the phagocytosis activity of macrophages in healthy patients. ASA 1-3 subjects undergoing extended shoulder surgery under continuous regional anesthesia randomly were assigned to a deep or a shallow anesthesia level (BIS \<35 or \>55) for more than an hour. Immune response is measured by lymphocyte proliferation as well as neutrophil and monocyte phagocytosis activity.

Conditions

  • Immunotoxicity
  • Anesthesia
  • Inert Gas Narcosis

Interventions

DRUG

High dose propofol, fentanyl and sevoflurane

Deep Anesthesia

DRUG

Low dose propofol, fentanyl and sevoflurane

Shallow Anesthesia

Sponsors & Collaborators

  • Heidelberg University

    lead OTHER

Principal Investigators

  • Thomas Frietsch, MD, PhD · University of Mannheim

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-03-31
Primary Completion
2012-03-31
Completion
2013-03-31

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02794896 on ClinicalTrials.gov