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Intravenous Lidocaine, Ketamine, and Magnesium in Thoracic Surgery

NCT07359469 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 118

Last updated 2026-01-22

No results posted yet for this study

Summary

Thoracic surgery often produces severe postoperative pain due to nerve injury and inflammation. Effective pain control is essential to reduce complications and opioid use. This prospective observational cohort study evaluated adult patients undergoing pulmonary resection by thoracotomy or video-assisted thoracoscopic surgery (VATS). The study examined whether intraoperative administration of intravenous lidocaine, ketamine, and magnesium, used as part of multimodal analgesia, was associated with reduced postoperative morphine consumption and lower early postoperative pain scores. Outcomes included 24-hour morphine use, pain intensity at 3 and 24 hours, complications, and chronic pain at 3 months. No study-directed interventions were performed; anesthetic management followed routine clinical practice.

Conditions

  • Postoperative Pain
  • Thoracic Surgery
  • Multimodal Analgesia
  • Opioid Consumption, Postoperative

Sponsors & Collaborators

  • Universidad Pública de Navarra

    lead OTHER

Principal Investigators

  • Manuel Murie Fernandez, MD, PhD · Universidad Pública de Navarra ( UPNA)

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-01-01
Primary Completion
2022-02-03
Completion
2022-05-03

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07359469 on ClinicalTrials.gov