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Pharmacokinetic Profile of Lidocaine Given as a Weight-based Infusion for Postoperative Surgical Pain Control

NCT05402293 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 7

Last updated 2026-02-09

No results posted yet for this study

Summary

Study Summary

Title Pharmacokinetic profile of lidocaine given as a weight-based infusion for postoperative surgical pain control

Short Title Pharmacokinetic profile of lidocaine given as a weight-based infusion for postoperative surgical pain control

Methodology Pharmacokinetic study of lidocaine in the surgical population

Study Duration 1 year

Study Center(s) University of Alberta Hospital

Objectives The primary objective will be to map serum lidocaine levels over time in a diverse surgical patient population receiving a weight-based lidocaine infusion.

Number of Subjects 40

Diagnosis and Main Inclusion Criteria ASA class 1-3 Age 18-40 or \>75 Scheduled for elective major ENT flap, urology or general surgery.

Study Product, Dose, Route, Regimen Lidocaine IV infusion

* 1.5mg/kg bolus, then
* 1mg/kg/h IV intraoperatively, then
* 0.5-2 mg/kg/hr IV for 48 h, depending on clinical response

Conditions

  • Acute Pain
  • Lidocaine
  • Administration and Dosage

Interventions

DIAGNOSTIC_TEST

Blood samples to measure lidocaine levels

Blood sampling is the only intervention Plasma samples will then be analyzed for lidocaine concentration

Sponsors & Collaborators

  • University of Alberta

    lead OTHER

Principal Investigators

  • James Green, MB BS · University of Alberta

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-02-12
Primary Completion
2025-03-12
Completion
2025-03-12

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05402293 on ClinicalTrials.gov