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The Application of T1 Mapping in Real-World

NCT07354646 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 2000

Last updated 2026-01-21

No results posted yet for this study

Summary

The goal of this observational study is to create a comprehensive real-world spectrum of T1 mapping measurements across different heart conditions. We aim to establish reference values for how heart tissue characteristics vary in various diseases, which will help doctors better interpret these advanced MRI measurements in clinical practice. The main questions it aims to answer are:

What are the normal T1 mapping values for different heart diseases, and how do they compare to healthy hearts? Can we use the simpler "native T1" measurement (without contrast dye) instead of the more complex "ECV" measurement (which requires contrast dye) for diagnosis?

Patients with various myocardial conditions will undergo CMR T1 mapping scans. We will analyze the MRI images and clinical records to establish disease-specific reference ranges for T1 mapping parameters, and validate the diagnostic accuracy of T1 mapping

Conditions

  • Myocardial Infarction (MI)
  • Hypertrophic Cardiomyopathy (HCM)
  • Dilated Cardiomyopathy (DCM)
  • Arrhythmogenic Cardiomyopathy
  • Myocarditis

Interventions

DIAGNOSTIC_TEST

Magnetic Resonance Imaging with Contrast

Participants in this arm undergo a single, standardized cardiac MRI scan with gadolinium-based contrast agent.

Sponsors & Collaborators

  • Chinese Academy of Medical Sciences, Fuwai Hospital

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-03-01
Primary Completion
2026-10-01
Completion
2026-12-01

Countries

  • China

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07354646 on ClinicalTrials.gov