Postoperative Acute Kidney Injury in Children Undergoing Major Non-cardiac Surgery

Summary

This project aims to conduct an international, prospective, multicentre, observational study to determine the incidence of Postoperative Acute Kidney Injury (PO-AKI) in hospitalized children after noncardiac surgery. Urinary biomarkers are intended to be evaluated as predictors of PO-AKI in the same subjects. The study employs modern standardized classifications for AKI to comprehensively address the issue of PO-AKI in children. Describing the incidence and identifying risk factors for PO-AKI will play a crucial role in developing preventive strategies aimed at reducing associated mortality and morbidity. Furthermore, investigating the relationship between urinary biomarkers of renal injury and PO-AKI will provide valuable insights into assessing postoperative renal function in paediatric patients, especially when repeated blood sampling is not feasible.

Conditions

• Acute Kidney Injury

Sponsors & Collaborators

• Uppsala University Hospital

  collaborator OTHER

• Karolinska Institutet

  collaborator OTHER

• Skane University Hospital

  collaborator OTHER

• Karolinska University Hospital

  collaborator OTHER

• Istituto Giannina Gaslini

  collaborator OTHER

• Queen Silvia Children's Hospital, Gothenburg, Sweden

  collaborator OTHER

• Feculdade de Medicina da Universidade de Sao Paulo - Brasil

  collaborator OTHER

• University of Belgrade

  collaborator OTHER

• University Hospital, Basel, Switzerland

  collaborator OTHER

• Hospices Civils de Lyon

  collaborator OTHER

• University of Bern

  collaborator OTHER

• University Hospital, Geneva

  collaborator OTHER

• Child and Adolescent Health Service - Perth

  collaborator OTHER_GOV

• Uppsala University

  lead OTHER

Principal Investigators

• Robert Frithiof, MD, PhD · Uppsala University Hospital, Uppsala, Sweden

Eligibility

Min Age

0 Years

Max Age

16 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-03-01

Primary Completion

2028-12-31

Completion

2028-12-31

Countries

• Australia
• Brazil
• France
• Italy
• Serbia
• Sweden
• Switzerland

Study Locations