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Repositioning the Bolus Tracking ROI to the Superior Vena Cava in CTPA Facilitates Contrast Volume Reduction

NCT07342374 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 72

Last updated 2026-01-15

No results posted yet for this study

Summary

This randomized controlled trial evaluates a protocol optimization for Computed Tomography Pulmonary Angiography (CTPA). The study investigates the impact of repositioning the bolus-tracking region-of-interest (ROI) from the standard pulmonary trunk (PT) to the superior vena cava (SVC). The goal is to compensate for the CT scanner's inherent transit delay time (TDT) to better align the scan with the peak arterial phase. By optimizing this timing, the study assesses whether contrast media volume can be safely reduced by 40% (from 50 ml to 30 ml) while maintaining diagnostic image quality and preventing venous contamination.

Conditions

  • Pulmonary Artery Embolism
  • Pulmonary Embolism (PE)

Interventions

DIAGNOSTIC_TEST

Optimized CTPA Protocol

CTPA scans are performed on a 128-slice CT scanner using the bolus tracking technique. Non-ionic contrast medium (370 mgI/ml) is administered at a rate of 4 ml/s, followed by a 20 ml saline flush. The diagnostic scan is automatically triggered when enhancement in the monitoring region of interest (ROI) reaches a threshold of 100 HU, with a fixed transit delay time (TDT) of 5 seconds.

Sponsors & Collaborators

  • Universiti Sultan Zainal Abidin

    collaborator OTHER

  • Hospital Queen Elizabeth, Malaysia

    lead OTHER_GOV

Principal Investigators

  • Kamarul Amin. bin Abdullah @ Abu Bakar., Assoc. Prof. Ts. Dr. · Universiti Sultan Zainal Abidin (UniSZA)

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-02-01
Primary Completion
2024-12-16
Completion
2024-12-16

Countries

  • Malaysia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07342374 on ClinicalTrials.gov