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Detection of Pulmonary Embolism With Low-dose CT Pulmonary Angiography

NCT01258140 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 504

Last updated 2013-01-23

No results posted yet for this study

Summary

Computed tomography pulmonary angiography (CTPA) is the imaging method of choice to rule out acute pulmonary embolism based on its high sensitivity and specificity. Unfortunately, CTPA uses iodinated contrast media and can provoke contrast induced nephropathy. On the other hand, Computed tomography uses ionising radiation and is responsible for the half of the radiation exposure coming from medical sources.

Recent studies have proven that low-dose CTPA protocols using Computed tomography tube energy of 80 kVp and reduced volume of iodinated contrast media provide an increased vessel signal and good image quality at a significantly reduced patient exposure. However, there are no data on the sensitivity of low-kVp protocols.

The aim of this prospective randomized trial is to detect any difference between a normal-dose and a low-dose CTPA protocol in the diagnostic accuracy in the detection of acute pulmonary embolism (PE).

Conditions

  • Embolism, Pulmonary

Interventions

RADIATION

Computed tomography pulmonary angiography

CT pulmonary angiography using iodinated contrast agent

RADIATION

Computed tomography pulmonary angiography

CT pulmonary angiography using iodinated contrast agent

Sponsors & Collaborators

  • Stanley Thomas Johnson Foundation, Bern, Switzerland

    collaborator UNKNOWN

  • Insel Gruppe AG, University Hospital Bern

    lead OTHER

Principal Investigators

  • Zsolt Szucs-Farkas, MD, PhD · Institute of Diagnostic, Interventional and Pediatric Radiology, University Hospital Bern

  • Zsolt Szucs-Farkas, MD, PhD · Hospital Centre Biel, Vogelsang 84, CH-2502 Biel/Bienne

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-09-30
Primary Completion
2012-12-31
Completion
2012-12-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01258140 on ClinicalTrials.gov