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Effect of Fruit Elicitation With Melatonin on Human Health

NCT07192835 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 22

Last updated 2025-09-25

No results posted yet for this study

Summary

The goal of this clinical trial is to learn if treating fruits with melatonin helps the body absorb and use healthy plant compounds. It will also learn how much melatonin from the fruits is taken up by the body. The main questions it aims to answer are:

* Does melatonin treatment of fruits raise the amount of healthy compounds the body absorbs?
* Does melatonin from treated fruits appear in urine after eating them?

Researchers will compare juice made from melatonin-treated fruits to juice made from untreated fruits to see if melatonin changes absorption.

Participants will:

* Follow a special low-plant-compound diet for 3 days before each test day
* Drink 300 grams of juice from treated or untreated fruit while fasting
* Provide urine samples before and after drinking the juice
* Return 15 days later to switch to the other juice type
* Repeat this process with lemon, blood orange, and cherry

Conditions

  • Healthy
  • Dietary Bioavailability
  • Plant Extracts
  • Phenolic Compounds
  • Melatonin

Interventions

DIETARY_SUPPLEMENT

Juice from untreated control fruits

Participants will consume 300 g of juice prepared from untreated fruits (lemon, blood orange, or sweet cherry) under fasting conditions on the intervention day. Urine samples will be collected at 0-3.5 h, 3.5-12 h, and 12-24 h post-consumption to assess absorption and metabolism of bioactive compounds.

DIETARY_SUPPLEMENT

Juice from melatonin-treated fruits

Participants will consume 300 g of juice prepared from fruits (lemon, blood orange, or sweet cherry) treated preharvest with melatonin (0.1, 0.3, or 0.5 mM). Juice will be consumed under fasting conditions on the intervention day. Urine samples will be collected at 0-3.5 h, 3.5-12 h, and 12-24 h post-consumption to assess absorption and metabolism of bioactive compounds.

Sponsors & Collaborators

  • National Research Council, Spain

    collaborator OTHER_GOV

  • Universidad Miguel Hernandez de Elche

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-03-01
Primary Completion
2025-08-01
Completion
2025-08-01

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07192835 on ClinicalTrials.gov