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Steroid Use in Treatment of Allergic Reactions to Food

NCT07341776 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 160

Last updated 2026-01-27

No results posted yet for this study

Summary

In this study, the investigators want to find out whether a specific medication commonly used for severe allergic reactions is really necessary. When children have allergic reactions to foods, they are often given medications to relieve the symptoms. In addition to adrenaline and antihistamines, steroids are frequently administered in German-speaking Switzerland. However, it is unclear whether steroids are really helpful in this situation. To investigate this, the investigators are comparing two groups: one group receives additional steroids, and the other does not. Which treatment a participant receives is decided randomly, like flipping a coin. The study takes place during a pre-scheduled provocation test at the clinic. If an allergic reaction occurs, the usual emergency medications will be administered. Doctors will closely monitor how the reaction develops. No additional tests or visits are required. The results of this study could help improve allergy treatment in the future.

Conditions

  • Anaphylactic Reaction
  • Anaphylaxis
  • Allergy in Children
  • IgE Mediated Food Allergy

Interventions

DRUG

Antihistamines

Oral administration of antihistamines for treatment of allergic symptoms during the oral food challenge.

DRUG

Systemic corticosteroids

Oral administration of systemic corticosteroids as adjunctive treatment of allergic reactions during the oral food challenge.

DRUG

Adrenaline (rescue medication)

Intramuscular administration of adrenaline as rescue treatment for severe allergic reactions (anaphylaxis), administered as clinically indicated.

Sponsors & Collaborators

  • University Children's Hospital Basel

    collaborator OTHER

  • Johannes Trueck

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
6 Months
Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-01-26
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • Switzerland

Study Locations

More Related Trials

Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07341776 on ClinicalTrials.gov