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Digital Speech Markers for Monitoring ALS in Spanish Speakers

NCT07341334 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 35

Last updated 2026-02-25

No results posted yet for this study

Summary

The goal of this observational study is to learn how speech and breathing change over time in Spanish-speaking individuals with amyotrophic lateral sclerosis (ALS) compared to age- and gender-matched individuals without ALS.

The main questions it aims to answer are:

Can speech and breathing measures collected through a smartphone application serve as reliable digital biomarkers to track bulbar disease decline in Spanish-speaking people with ALS?

How do these measures differ between individuals with ALS and those without ALS?

Researchers will compare Spanish-speaking participants with ALS to age- and gender-matched healthy controls to see if specific speech and breathing features can identify or predict bulbar decline.

Participants will:

Use a Spanish-language smartphone application to record speech and breathing tasks over time.

Complete assessments of speech, breathing, and functional abilities (e.g., ALS Functional Rating Scale).

Provide data that will be compared to caregiver reports and clinical outcomes to validate new digital biomarkers.

Conditions

Sponsors & Collaborators

  • Peter Cohen Foundation (PCF)

    collaborator OTHER

  • Nova Southeastern University

    lead OTHER

Principal Investigators

  • Lauren Tabor Gray, Ph.D CCC-SLP · Nova Southeastern University

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-04-30
Primary Completion
2029-12-31
Completion
2029-12-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07341334 on ClinicalTrials.gov