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Does Vitamin C Increase the Body Heat Generated By The Nervous System?

NCT07341308 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2026-01-14

No results posted yet for this study

Summary

The goals of this clinical trial are to determine whether or not vitamin C is able to: (1) increase the body heat generated by the sympathetic nervous system; and, (2) increase circulating vitamin D concentration during sympathetic nervous system stimulation in adult humans aged 18-40 years who meet the criteria for overweight based on body mass index. The main question it aims to answer are:

1. By how much does body temperature increase during stimulation of beta-adrenergic receptors when vitamin C is given.
2. By how much does circulating vitamin D concentration increase during stimulation of beta-adrenergic receptors when vitamin C is given.

Participants will will be asked to:

* undergo measures of body temperature
* have blood sampled on two separate occasions: once during stimulation of beta adrenergic receptors, and once during stimulation of beta-adrenergic receptors while also been given vitamin C.

Conditions

  • Metabolism Changes
  • Vitamin D

Interventions

OTHER

Vitamin C

Vitamin C will be co-infused with isoproterenol

Sponsors & Collaborators

  • Colorado State University

    lead OTHER

Principal Investigators

  • Christopher Bell, PhD · Colorado State University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-03-17
Primary Completion
2026-06-08
Completion
2026-12-08

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07341308 on ClinicalTrials.gov