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Effects of Magnesium Sulfate on Oxygenation and Lung Mechanics During One-Lung Ventilation

NCT07325773 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 104

Last updated 2026-01-08

No results posted yet for this study

Summary

This prospective observational study aims to evaluate the effects of intravenous magnesium sulfate on intraoperative oxygenation and lung mechanics in patients undergoing thoracic surgery with one-lung ventilation. Magnesium sulfate has been reported to have potential bronchodilatory and anti-inflammatory properties, which may improve gas exchange and respiratory mechanics during lung isolation.

In this study, patients who receive magnesium sulfate as part of standard anesthetic management will be compared with those who do not receive the drug. Oxygenation parameters, dynamic and static lung mechanics, airway pressures, and ventilation-related indices will be recorded throughout the intraoperative period. The findings of this study may help clarify whether magnesium sulfate provides measurable respiratory benefits during one-lung ventilation.

Conditions

  • Intraoperative Oxygenation and Pulmonary Mechanics

Sponsors & Collaborators

  • Marmara University

    lead OTHER

Principal Investigators

  • Meliha ORHON ERGÜN · Marmara University Faculty of Medicine, Department of Anesthesiology and Reanimation

  • İlayda AKARSU KAYA · Marmara University Faculty of Medicine, Department of Anesthesiology and Reanimation

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-12-01
Primary Completion
2026-07-15
Completion
2026-11-28

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07325773 on ClinicalTrials.gov