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Meropenem vs Azithromycin Efficacy in Case XDR Enteric Fever

NCT07314281 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2026-05-08

No results posted yet for this study

Summary

1. Primary Objective:

o To evaluate the efficacy of intravenous azithromycin compared with meropenem in the treatment of extensively drug-resistant (XDR) enteric fever.
2. Secondary Objectives:

* To evaluate the fever defervescence and Salmonella Typhi eradication
* To evaluate the cost-effectiveness of intravenous azithromycin versus meropenem in treating XDR enteric fever.
3. Exploratory Objectives:

* To evaluate the drug resistance against intravenous azithromycin versus in treating XDR enteric fever.

Conditions

  • Enteric Fever

Interventions

DRUG

Azithromycin

Azithromycin 1g IV loading dose then 500mg IV OD

DRUG

Meropenem Injection

Meropenem 1000 mg IV Q8H

Sponsors & Collaborators

  • Indus Hospital and Health Network

    lead OTHER

Principal Investigators

  • muhammad hamid · Indus Hospital and Health Network

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
1 Year
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-04-22
Primary Completion
2027-01-15
Completion
2027-01-15

Countries

  • Pakistan

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07314281 on ClinicalTrials.gov