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Ultra-Low-Flow Anesthesia and Carbon Footprint

NCT07313969 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 92

Last updated 2026-01-27

No results posted yet for this study

Summary

This is a prospective, randomized controlled clinical trial evaluating the effects of ultra-low fresh gas flow (0.5 L/min) versus normal fresh gas flow (2.0 L/min) sevoflurane anesthesia in adult patients undergoing on-pump cardiac surgery. The study aims to determine whether ultra-low-flow anesthesia can be used safely to reduce volatile anesthetic consumption and environmental emissions without compromising hemodynamic stability or anesthetic depth.

Eligible adult patients scheduled for elective coronary artery bypass grafting (CABG) or valve surgery under general anesthesia will be randomized in a 1:1 ratio to one of two groups: ultra-low-flow (0.5 L/min) or normal-flow (2.0 L/min). All other anesthetic techniques, including induction drugs, ventilation parameters, temperature management, and perfusion strategies, will be standardized.

The primary outcome is the total amount of sevoflurane consumed per case. Secondary outcomes include intraoperative hemodynamic parameters (heart rate, mean arterial pressure), depth of anesthesia (BIS/MAC values), postoperative recovery times, and estimated carbon dioxide equivalent (CO₂e) emissions.

Outcome assessors and data analysts will remain blinded to group allocation. The findings of this study are expected to provide new evidence regarding the safety, efficiency, and environmental benefits of ultra-low-flow anesthesia techniques in cardiac surgery.

Conditions

  • Low Flow Anesthesia
  • Sevoflurane Anesthesia
  • Cardiac Surgery

Interventions

DRUG

ultra low flow anesthesia

General anesthesia will be maintained with sevoflurane at a fresh gas flow rate of 0.5 L/min using oxygen and air mixture. The flow rate will be kept constant from post-induction stabilization until the end of cardiopulmonary bypass.

DRUG

normal flow anesthesia

General anesthesia will be maintained with sevoflurane at a fresh gas flow rate of 2.0 L/min using oxygen and air mixture. The flow rate will be kept constant from post-induction stabilization until the end of cardiopulmonary bypass.

Sponsors & Collaborators

  • Ankara Etlik City Hospital

    collaborator OTHER_GOV

  • Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-07-30
Primary Completion
2025-09-15
Completion
2026-01-15

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07313969 on ClinicalTrials.gov