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Surgical Outcomes in Splenic Flexure Cancers: A Multicenter Comparison of Segmental vs. Extended Hemicolectomy (SPARROW Study)

NCT07289568 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 140

Last updated 2025-12-17

No results posted yet for this study

Summary

SPARROW Study: Surgical Outcomes in Splenic Flexure Cancer

Colonic cancers located at the splenic flexure where the transverse colon turns into the descending colon are uncommon and represent less than 10% of all colorectal cancers. Because of their unique location between the blood supply of the right and left colon, there is no clear agreement on which surgical method provides the best results.

Two main procedures are used:

Segmental hemicolectomy, which removes only the part of the colon containing the tumor, and

Extended hemicolectomy, which removes a larger section of the colon and more lymph nodes.

The SPARROW Study is a prospective, multicenter observational study designed to compare these two surgical approaches in patients with splenic flexure cancer. The study will include about 140 patients (70 in each group) from multiple tertiary colorectal centers in Turkey and Europe.

Researchers will collect information about each patient's surgery, recovery, and follow-up outcomes. The main outcomes include postoperative ileus, leakage at the surgical connection (anastomosis), wound infection, and total postoperative complications. Other outcomes include number of lymph nodes removed, complete tumor resection (R0), hospital stay, recovery time, reoperation, and 3-year overall and disease-free survival.

By analyzing both short- and long-term results, the SPARROW Study aims to provide high-quality evidence to guide surgeons in choosing the best and safest operation for patients with splenic flexure cancers.

All participants will provide written informed consent before joining the study. The study has received ethical approval from the Koç University Ethics Committee and will be conducted in accordance with the Declaration of Helsinki.

Conditions

  • Colon Cancer
  • Splenic Flexure Mobilization
  • Right Hemicolectomy
  • Left Hemicolectomy
  • Segmental Colectomy
  • Extended Hemicolectomy

Interventions

PROCEDURE

Colectomy

Extended hemicolectomy involves removal of a larger segment of colon that includes the splenic flexure tumor and its associated lymphatic drainage. The procedure typically includes ligation of the relevant feeding arteries-such as the right, middle, and left colic branches-and resection of adjacent colon segments to achieve an oncologically adequate specimen with tension-free anastomosis. The extent of resection and vascular ligation is determined according to surgeon preference and tumor location. This approach may be performed using open, laparoscopic, or robotic techniques, depending on institutional practice.

Sponsors & Collaborators

  • Acibadem University

    lead OTHER

Principal Investigators

  • Bilgi Baca, MD, Professor of Surgery · Acibadem University Istanbul Turkey

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-10-05
Primary Completion
2028-10-31
Completion
2030-10-31

Countries

  • Turkey (Türkiye)

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07289568 on ClinicalTrials.gov