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Surgical Outcome and Predictors of Overall Survival of Stage I-III Appendiceal Adenocarcinoma

NCT05452382 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 2607

Last updated 2022-07-11

No results posted yet for this study

Summary

A few studies investigated the predictors of overall survival in appendiceal adenocarcinoma. A SEER database analysis of 1404 patients with appendiceal adenocarcinoma found that older age, T4 tumors, N1-2 stage, poorly differentiated carcinoma, and distant metastasis were significantly predictive of poorer survival. Another small single-center study including 49 appendiceal cancer patients reported female gender and low-grade adenocarcinoma to be associated with increased overall survival. However, these previous analyses did not take into account some important prognosticators of survival such as patients' comorbidities and functional status, pathologic parameters such as lymphovascular invasion, and adjuvant systemic treatment. Therefore, we used the National Cancer Database (NCDB) to conduct a comprehensive analysis of the predictors of overall survival after surgical treatment of stage I-III appendiceal adenocarcinoma.

Conditions

  • Appendiceal Cancer

Interventions

PROCEDURE

Partial colecctomy

Segmental resection of appendiceal adenocarcinoma including terminal ileum and cecum

PROCEDURE

Hemicolectomy

Formal right hemicolectomy including terminal ileum, cecum, and ascending colon

Sponsors & Collaborators

  • Cleveland Clinic Florida

    collaborator OTHER

  • Mansoura University

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2005-01-01
Primary Completion
2019-12-30
Completion
2022-07-06

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05452382 on ClinicalTrials.gov