MedTrace Logo

Protocolised Management of Phosphate Replacement Trial

NCT07288944 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 2400

Last updated 2025-12-17

No results posted yet for this study

Summary

The aim of this cluster, crossover, randomised controlled trial is to compare two standard arms of treatment for the replacement of phosphate in critically ill patients.

We hypothesise that protocolised restricted phosphate replacement, compared to protocolised liberal phosphate replacement, will result in reduced administration of phosphate with similar clinical outcomes.

All eligible Intensive Care Unit (ICU) patients will be included during their admission with the selected protocol for that period as per usual practice and treatment standards.

Conditions

  • Phosphate Deficiency
  • Hypophosphatemia
  • Protocol Optimization
  • Critical Care, Intensive Care

Interventions

OTHER

Liberal Phosphate Replacement Protocol

The liberal group, a recommendation for phosphate replacement would be given if the serum phosphate concentration was 0.79 mmol/L, but not if 0.80 mmol/L.

OTHER

Restrictive Phosphate Replacement Protocol

The restrictive protocol will recommend phosphate replacement to commence at a threshold of 0.50 mmol/L, and the liberal protocol at 0.80 mmol/L.

Sponsors & Collaborators

  • Queensland University of Technology

    collaborator OTHER

  • Caboolture Hospital

    lead OTHER_GOV

Principal Investigators

  • Mahesh Ramanan · +61 7 5433 8888

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-01-31
Primary Completion
2027-02-28
Completion
2027-12-31

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07288944 on ClinicalTrials.gov