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Single-cell Multiomics and Spatiotemporal Omics Analyze the Mechanism of Liver Degenerative Disease

NCT07265544 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 240

Last updated 2026-04-14

No results posted yet for this study

Summary

The purpose of this observational study is to employ single-cell multi-omics and spatial omics technologies to characterize the spatial and immune structures within the livers of patients with fatty liver, hepatic hemangioma, focal nodular hyperplasia, liver fibrosis, cirrhosis, and HBV infection. The primary questions it aims to address are:

Investigate the mechanisms of liver degenerative changes during the processes of liver aging, fatty liver, HBV infection, liver fibrosis, and cirrhosis.

Characterize the molecular features and cellular networks at different stages of liver degeneration and identify new targets and mechanisms for the cure of the aforementioned diseases.

The study will collect peripheral blood and discarded liver tissue from patients with hepatic hemangioma, fatty liver, HBV infection, liver fibrosis, and cirrhosis who are undergoing hepatectomy or liver biopsy.

Conditions

  • Liver Neoplasm
  • HBV Infection
  • Non-alcoholic Fatty Liver Disease NAFLD
  • Liver Fibrosis

Interventions

PROCEDURE

Collection of Preoperative Peripheral Blood

Prior to surgery, 30 milliliters of peripheral blood will be drawn from the subject's upper limb.

PROCEDURE

Collection of Discarded Liver Tissue During Surgery

From subjects undergoing hepatectomy or liver biopsy, discarded liver tissue will be collected during the surgical procedure.

Sponsors & Collaborators

  • Beijing Friendship Hospital

    collaborator OTHER

  • Beijing YouAn Hospital

    collaborator OTHER

  • Zhongnan Hospital

    collaborator OTHER

  • Guangzhou General Hospital of Guangzhou Military Command

    collaborator OTHER

  • Nanfang Hospital, Southern Medical University

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-03-01
Primary Completion
2026-12-31
Completion
2027-02-12

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07265544 on ClinicalTrials.gov