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3D-CT-Based Prediction of Difficult Laryngoscopy in Infants With Pierre Robin Sequence

NCT07257276 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 294

Last updated 2025-12-02

No results posted yet for this study

Summary

This study aims to develop and validate a quantitative prediction model using three-dimensional computed tomography (3D-CT) imaging for identifying infants with Pierre Robin sequence (PRS) at risk of difficult laryngoscopy. A dual-parameter model incorporating the oropharyngeal sagittal area (S2) and the distance between the tongue base and the posterior pharyngeal wall (D4) will be established. Internal validation will be performed using data from PRS infants treated between 2023 and 2024, and temporal external validation will be conducted using an independent cohort from 2025.

This study seeks to provide an accurate, non-invasive tool for preoperative airway risk assessment in PRS infants, thereby improving anesthetic safety and clinical decision-making.

Conditions

  • Pierre Robin Sequence (PRS)
  • Difficult Laryngoscopy
  • Airway Management

Sponsors & Collaborators

  • Nanjing Children's Hospital

    lead OTHER

Eligibility

Min Age
0 Days
Max Age
3 Months
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-01-01
Primary Completion
2024-12-31
Completion
2025-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07257276 on ClinicalTrials.gov