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Effects of a Multicomponent Training Program on Cardiac Function, Skeletal Muscle Metabolism, Functional Capacity, and Quality of Life in Patients With HFpEF: SENSORFIT-4HEART Study

NCT07251361 · Status: ENROLLING_BY_INVITATION · Phase: NA · Type: INTERVENTIONAL · Enrollment: 150

Last updated 2025-11-26

No results posted yet for this study

Summary

Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome with increasing incidence and poor prognosis, accounting for up to 50% of heart failure cases. It is strongly associated with aging, cardiovascular risk factors (hypertension, diabetes, obesity), and is more prevalent in women than men. Patients with HFpEF frequently present with dyspnea, debilitating fatigue, poor quality of life, frequent hospitalizations, and high mortality rates. This study aims to evaluate the effects of a structured exercise program on cardiac function, skeletal muscle metabolism, functional capacity, and quality of life in patients with HFpEF, and to explore whether these benefits are mediated by circulating exerkines.

Conditions

  • Heart Failure With Preserved Ejection Fraction (HFPEF)

Interventions

BEHAVIORAL

Supervised training

Supervised training

Sponsors & Collaborators

  • NavarraBiomed Biomedical Research Center

    collaborator OTHER

  • Centro de Investigación Médica Aplicada (CIMA)

    collaborator UNKNOWN

  • Complejo Hospitalario de Navarra

    collaborator OTHER

  • Instituto de Investigación Sanitaria de Navarra (IdiSNA)

    collaborator UNKNOWN

  • Universidad Pública de Navarra

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-01-20
Primary Completion
2025-02-01
Completion
2026-12-20

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07251361 on ClinicalTrials.gov