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ClusterVAP: Multicentre Proteomic Endotyping of Ventilator-associated Pneumonia

NCT07245888 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 400

Last updated 2025-11-24

No results posted yet for this study

Summary

Ventilator-associated pneumonia (VAP) is a common and serious infection in patients receiving mechanical ventilation in intensive care units. Current diagnostic methods are imprecise, leading to unnecessary antibiotic use and delayed treatment. The ClusterVAP study aims to identify biologically and clinically distinct subgroups of patients with suspected VAP by analyzing proteins in bronchoalveolar lavage (BAL) fluid using advanced proteomic techniques. This multicentre observational study will enroll approximately 400 adult patients from intensive care units in Sweden, France, Portugal, Denmark, and the United Kingdom. BAL or mini-BAL samples collected for clinical reasons will be analyzed to define "pneumoclusters" and explore their association with patient outcomes. The study will also identify candidate biomarkers that could support future diagnostic tools. No experimental treatments are given; all patients receive standard care. Results may improve diagnostic accuracy and guide personalized treatment strategies for critically ill patients.

Conditions

  • Ventilator Acquired Pneumonia
  • Mechanical Ventilation Complication

Sponsors & Collaborators

  • Lund University

    collaborator OTHER

  • NOVA Medical School

    collaborator OTHER

  • Rigshospitalet, Denmark

    collaborator OTHER

  • Karolinska University Hospital

    collaborator OTHER

  • University Hospital, Limoges

    collaborator OTHER

  • King's College Hospital NHS Trust

    collaborator OTHER

  • Umeå University

    collaborator OTHER

  • Region Skane

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-11-30
Primary Completion
2027-05-31
Completion
2027-05-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07245888 on ClinicalTrials.gov