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Immunity Markers in Intensive Care Patients and Ventilator-associated Pneumonia

NCT06607055 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2024-09-23

No results posted yet for this study

Summary

The goal of this observational study is to show the direct correlation between the occurrence of recurrence of VAP and postagressive immunoparalysis, monitored by HLA-DR rate below litterature-acknowledged threshold, in a well conducted antibiotherapy context, in patient admitted in the Intensive Care Unit.

The main questions it aims to answer are:

* evaluation of the association between death and persistence of immunoplegia using HLA-DR monitoring
* search an association between immunoplegia depth and severity of the initial state of shock
* search an association between immunoplegia depth and viral reactivation
* compare association of immunoplegia duration and HLA-DR nadir and VAP occurrence Blood samples will be taken from participants to HLA-DR dosage, at the time of inclusion and once a week then.

Conditions

  • Pneumonia, Ventilator-Associated

Interventions

DIAGNOSTIC_TEST

Blood collection

HLA-DR dosage, at the time of inclusion and once a week then

Sponsors & Collaborators

  • Centre Hospitalier Intercommunal Aix-Pertuis

    lead OTHER

Principal Investigators

  • Laurent LEFEBVRE, MD · Centre Hospitalier Intercommunal Aix-Pertuis

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-10-04
Primary Completion
2025-09-30
Completion
2025-09-30

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06607055 on ClinicalTrials.gov