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Cross-linked Hyaluronic Acid in Knee Osteoarthritis

NCT07241442 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 88

Last updated 2026-02-27

No results posted yet for this study

Summary

Knee Osteoarthritis (Knee OA) leads to pain and loss of function, especially in recreational athletes. While hyaluronic acid (HA) injections are a common part of conservative treatment, comparative data on the efficacy of straight-chain (ST-HA) versus cross-linked (CL-HA) formulations remain limited. Therefore, the aim of this study was to compare the 6-month efficacy of a single dose of CL-HA versus two doses of ST-HA regarding pain, stiffness, and joint function in recreational athletes aged 50-70 with Kellgren-Lawrence grade 2-3 Knee OA refractory to pharmacological treatment.

Conditions

  • Knee Osteoarthritis (Knee OA)

Interventions

DRUG

Straight-bonded hyaluronic acid

Straight-bonded HA injection was applied in 2 doses, 4 weeks apart.

DRUG

cross-linked hyaluronic acid

Cross-linked HA was applied as a single dose to the knee via the anterolateral approach.

Sponsors & Collaborators

  • Istanbul Medipol University Hospital

    lead OTHER

Eligibility

Min Age
50 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-01-02
Primary Completion
2024-12-31
Completion
2025-05-31

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07241442 on ClinicalTrials.gov