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DEXDES Trial: Dexmedetomidine-Desflurane Combination in Laparoscopic Colectomy

NCT07239479 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2025-12-30

No results posted yet for this study

Summary

This randomized double-blind controlled clinical trial aims to evaluate the efficacy and safety of combining Dexmedetomidine with Desflurane in patients undergoing elective laparoscopic colectomy. The study will assess whether the combination can reduce Desflurane consumption, improve intraoperative hemodynamic stability, and enhance postoperative recovery compared to Desflurane alone.

Conditions

  • Colorectal Neoplasms

Interventions

DRUG

Dexmedetomidine + Desflurane

Dexmedetomidine bolus 1 µg/kg IV over 15 minutes before induction, followed by continuous infusion 0.5 µg/kg/h during surgery. Desflurane administered at 1 MAC with EtControl mode.

DRUG

Desflurane + Normal Saline

Normal saline infusion with identical timing and volume as the intervention group. Desflurane administered at 1 MAC with EtControl mode.

Sponsors & Collaborators

  • Tam Anh TP. Ho Chi Minh General Hospital

    collaborator OTHER

  • Tam Anh Research Institute

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-12-01
Primary Completion
2026-12-31
Completion
2027-01-30

Countries

  • Vietnam

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07239479 on ClinicalTrials.gov