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Implementation of Screen, Treat, and Triage for Women Living With HIV in La Romana (iSTAR)

NCT07225530 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 600

Last updated 2026-02-25

No results posted yet for this study

Summary

This study aims to conduct a randomized controlled trial to evaluate the effectiveness of same-day HPV-based screen and treat among women living with HIV (WLH) in La Romana, Dominican Republic. With cervical cancer being a leading cause of cancer-related deaths in women living with HIV, and cervical cancer deaths being preventable through screening and early detection, this project seeks to identify factors associated with the successful implementation of the Screen, Triage, and Treat approach to inform future implementation and scale-up.

Conditions

Interventions

OTHER

Screen, Triage, and Treat

A screening test is used to determine who is eligible for treatment, eliminating steps related to histological confirmation. Those who meet the HPV criteria will be immediately evaluated for suitability for on-site ablative treatment on the same day. Women not suitable for treatment will be referred for colposcopy and further management at the appropriate facility.

Sponsors & Collaborators

  • National Cancer Institute (NCI)

    collaborator NIH

  • Clínica de Familia La Romana, Dominican Republic

    collaborator UNKNOWN

  • Columbia University

    lead OTHER

Principal Investigators

  • Rebecca Schnall, PhD, MPH · Columbia University

Study Design

Allocation
RANDOMIZED
Purpose
SCREENING
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
25 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-02-23
Primary Completion
2029-05-01
Completion
2029-11-01

Countries

  • Dominican Republic

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07225530 on ClinicalTrials.gov