HPV infection is infection with human papillomavirus, a common sexually transmitted viral infection. Most infections are asymptomatic and resolve spontaneously, but persistent infection with high-risk HPV types can lead to cancers including cervical, anal, penile, and oropharyngeal cancers. Vaccination significantly reduces infection and related disease risk.
Class action lawsuits allege securities violations by Atara Biotherapeutics and Inovio Pharmaceuticals related to FDA submissions. Atara faces claims over manufacturing issues with its tabelecleucel BLA, while Inovio is accused of misleading statements about INO-3107 regulatory timelines and manufacturing deficiencies.
New research shows HPV vaccination provides sustained protection against invasive cervical cancer for over a decade, with vaccinated individuals showing significantly lower cancer rates. The study found 79% lower risk for those vaccinated before age 17, with protection lasting 13-15 years. Cervical cancer remains a major global health challenge, particularly in regions like India and the Caribbean where infection rates are high.
Australia's National Health and Medical Research Council marks 90 years of funding medical breakthroughs while facing warnings that research institutes could exhaust capital within a decade. The NHMRC's success includes funding the HPV vaccine that put Australia on track to eliminate cervical cancer by 2035, but sustained funding is needed to maintain world-class research capabilities.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07593066 |
PRIORITY Study in Cervical Cancer |
NOT_YET_RECRUITING | |
| NCT07572396 |
Phase II Study of Dysplasix™ Intravaginal Suppositories in Patients Patients With High-Risk HPV and Mild Cervical Cytologic Abnormalities |
RECRUITING | PHASE2 |
| NCT07545746 |
Adjuvant 5-Fluorouracil Following Thermal Ablation to Improve HPV Treatment Outcomes in Women With HIV in Kenya |
NOT_YET_RECRUITING | PHASE2 |
| NCT07453459 |
Feasibility of HPV Self-Collection Kits for Cervical Cancer Screening |
RECRUITING | NA |
| NCT07428330 |
Clinic vs Clinic+Community Outreach HPV Self-Collection to Increase Cervical Screening in Women With HIV |
RECRUITING | NA |
| NCT07344337 |
Evaluation of the Effect of a Dietary Supplement Based on EGCG, Vitamin B12, Hyaluronic Acid, and Folic Acid on the Maintenance of Physiological Balance and the Natural Defenses of the Male Genital System in Subjects Exposed to HPV Infection. |
NOT_YET_RECRUITING | NA |
| NCT07336134 |
PopSci CHW4CervixHealth |
RECRUITING | NA |
| NCT07281677 |
Immunogenicity and Safety of Sequential 2vHPV-9vHPV Vaccination in Girls Aged 9-14 Years |
RECRUITING | PHASE4 |
| NCT07281599 |
Evaluation of the Q-Pad hrHPV Test System for Identifying Precancer |
RECRUITING | NA |
| NCT07225530 |
Implementation of Screen, Treat, and Triage for Women Living With HIV in La Romana (iSTAR) |
RECRUITING | NA |
