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Exercise and Mortality in Middle-Aged and Older Adults

NCT07224659 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 19000

Last updated 2026-02-04

No results posted yet for this study

Summary

This protocol is a retrospective study using the observational data of the the Prostate, Lung, Colorectal, and Ovarian (PLCO) screening trial with over 150,000 participants aged 55-74 years to conduct a target trial emulation to examine the association between self-reported exercise and all cause and cause-specific mortality in apparently healthy, middle-aged and older adults. The PLCO includes assessments of participants' exercise level at two timepoints: at randomization into the PLCO trial (Q0) and 5-7 years after randomization into the PLCO (Q1).

Conditions

  • Overall Survival (All-cause Mortality)

Interventions

BEHAVIORAL

Control

0 or less than 1 day per week, with each session, on average \< 15 minutes.

BEHAVIORAL

Exercise

\>/= 2 days per week of moderate or vigorous intensity, with each session, on average, \>/=20 minutes in duration.

Sponsors & Collaborators

  • City of Hope Medical Center

    lead OTHER

Eligibility

Min Age
55 Years
Max Age
74 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-04-01
Primary Completion
2026-08-06
Completion
2026-08-06

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07224659 on ClinicalTrials.gov