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Prebiotics (Dried Plum) and Immune Function in Postmenopausal Women

NCT07222111 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2025-10-29

No results posted yet for this study

Summary

Prior studies have shown that dietary supplementation with dried plums (also known as prunes) reduces bone loss in postmenopausal women. The purpose of this clinical trial is to understand how dried plums mediate their effects on bone. The main questions the study will answer are:

1. Does adding dried plums to the diet alter immune cell function?
2. Does dried plum alter gut microbes?
3. Does a person's vitamin D status influence this response?

Researcher will compare the response following consumption of the normal diet to supplementing the diet with dried plums.

Participant will:

1. Consume their normal diet or supplement their normal diet dried plums for four week periods over the course of 3-4 months.
2. Complete 5 study visits scheduled.
3. Perform some physical function tests and have a bone density scan at the beginning of the study.
4. Complete questionnaires, a 3-day food record, and provide stool and blood samples at 4 different timepoints during the study.
5. Record information about their bowel habits

Conditions

  • T Cell Response to Dried Plum
  • Vitamin D Influence on Immune Response
  • Dried Plum and Immune Function

Interventions

DIETARY_SUPPLEMENT

Dried plums

Participants will supplement their regular diet with 50 g of dried plum (5-6 dried plums) per day.

Sponsors & Collaborators

  • Indiana University School of Medicine

    collaborator OTHER

  • Purdue University

    collaborator OTHER

  • Indiana University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
60 Years
Max Age
75 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-09-02
Primary Completion
2027-08-30
Completion
2028-08-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07222111 on ClinicalTrials.gov