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Evaluation of Physiological and Psychological Factors Involved in Exercise Intolerance in Patients With β-TTD

NCT07207577 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2025-10-06

No results posted yet for this study

Summary

The goal of this clinical trial is to compare physical ability of patients with transfusion-dependent β-thalassemia to control subjects. The main question it aims to answer is:

is there a difference in power output at first lactate threshold between patients with transfusion-dependent β-thalassemia and control subjects during maximal incremental exercise test.

Participants will have to realise differents exams including measurement of body compposition, maximal incremental exercise test, vertical jump, vasoreactivity test, blood sampling, quality of life questionnaires and neuromuscular assessments.

Conditions

  • Beta Thalassemia Transfusion Dependent

Interventions

OTHER

Maximal incremental exercise test

Participants will perform a symptom-limited maximal incremental exercise test on a cycle ergometer.

Sponsors & Collaborators

  • Université Savoie Mont Blanc

    collaborator OTHER

  • Laboratoire de Psychologie et NeuroCognition (LPNC), Université Grenoble Alpes

    collaborator UNKNOWN

  • Centre Hospitalier Metropole Savoie

    lead OTHER

Principal Investigators

  • Laurent MESSONNIER · Université Savoie Mont Blanc

  • Pierre FAURIE · CH Metropole Savoie

  • Mathilde NOGUER · Université Savoie Mont Blanc

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-09-04
Primary Completion
2028-10-31
Completion
2028-10-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07207577 on ClinicalTrials.gov