Fatigability Compared Men and Women Induced According to the Distance Traveled on an Ultra-marathon in the Mountains

Summary

Acute physiological consequences of ultra-marathon running are still unknown, particularly in women. Some studies have suggested that the proportion of fatigue attributable to peripheral and central mechanisms varies between males and females; however, results are contradictory.

The results from the investigators of the present experiment in two studies conducted in 2009 and 2012 showed that:

* A large part of fatigue induced by a mountain ultra-marathon could be attributed to central fatigue in males and that,
* Females exhibited less peripheral fatigue in the plantar flexors than males did after a 110-km ultra-trail-running race.

According to the literature, there seems to be a plateau in fatigue after 12-15 hours of running.

Conditions

• Ultra-marathon Runners

Interventions

OTHER

Neuromuscular tests in isometric mode

Protocol for neuromuscular tests in isometric mode will be assessed by the composite of these measures : * Voluntary maximum forces plantar flexors and knee extensors * Electrically evoked forces * ElectroMyoGraphic activity (EMG) * Three-Modality Evoked Potentials (TMEPs)

DEVICE

Transcranial Magnetic Stimulation (TMS)

Measure of supraspinal activation level and cortical excitation by Transcranial Magnetic Stimulation (TMS).

OTHER

Neuromuscular fatigue assessment test

Neuromuscular fatigue assessment test in dynamic mode will be assessed by the Force/Velocity Profile (FVP) measure: 2 sprints of 8 seconds on a cycle ergometer.

OTHER

treadmill

2 sessions of treadmill will be realized: 8 and 10 km.h-1 for level running and 7 km.h-1 with 10% slope for graded running.

BIOLOGICAL

Blood sample

Blood sample will be realized to measure hemorrheologic and hematologic parameters.

BIOLOGICAL

Urinary sample

Urinary sample will be realized to measure hemorrheologic and hematologic parameters.

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Saint Etienne

  lead OTHER

Principal Investigators

• Léonard FEASSON, MD PhD · CHU SAINT-ETIENNE

• Guillaume MILLET, PhD · University of Saint-Etienne

Study Design

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2019-07-02

Primary Completion

2019-09-01

Completion

2019-09-01

Countries

• France

Study Locations