Six Versus Twelve Month Index Follow-up After Large Colon Polyp Resection

Summary

The study will compare the use of a 6-month follow-up vs a 12-month follow-up after the removal of a large non-pedunculated polyp 20-50mm in size and without high grade dysplasia.

Conditions

• Colon Cancer
• Colon Polyp
• Adenoma
• Serrated Polyp
• Recurrence, Local Neoplasm
• Endoscopic Resection

Interventions

PROCEDURE

6-month follow-up

Eligible patients randomized to the 6-month follow-up arm will undergo their first surveillance procedure 6 months after the removal of their large polyp to check for recurrent polyp tissue.

PROCEDURE

12-month follow-up

Eligible patients randomized to the 12-month follow-up arm will undergo their first surveillance procedure 12 months after the removal of their large polyp to check for recurrent polyp tissue.

Sponsors & Collaborators

• Rush University Medical Center

  collaborator OTHER

• University of Colorado, Denver

  collaborator OTHER

• White River Junction Veterans Affairs Medical Center

  collaborator FED

• University of Kansas Medical Center

  collaborator OTHER

• University of British Columbia

  collaborator OTHER

• University of Alabama at Birmingham

  collaborator OTHER

• Beth Israel Deaconess Medical Center

  collaborator OTHER

• Henry Ford Hospital

  collaborator OTHER

• University Medical Centre Ljubljana

  collaborator OTHER

• Indiana University

  lead OTHER

Principal Investigators

• John J Guardiola, MD · Indiana University

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-05-31

Primary Completion

2029-11-30

Completion

2030-01-31

Countries

• United States

Study Locations