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Equivalent MAC in General Anesthesia

NCT07197567 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2026-03-10

No results posted yet for this study

Summary

This observational study aims to evaluate the clinical applicability of the Equivalent Minimum Alveolar Concentration (eMAC) parameter during general anesthesia. eMAC is a recently developed index that combines the effects of both inhalational and intravenous anesthetics, providing a unified measure of anesthetic depth. While the traditional Minimum Alveolar Concentration (MAC) is widely used for inhalational agents, it does not reflect intravenous anesthetics or combined techniques such as Combined Intravenous and Inhalational Anesthesia (CIVIA).

In this study, adult patients undergoing elective surgery under general anesthesia will be observed. Standard clinical practice will not be altered. Demographic and clinical parameters, including eMAC, MAC, Bispectral Index (BIS), and hemodynamic variables, will be recorded at defined perioperative time points. No experimental drugs or additional procedures will be administered.

The primary aim is to investigate the correlation between eMAC and MAC values obtained during anesthesia. Secondary objectives include assessing the relationship between eMAC and BIS values, comparing eMAC, MAC, and BIS across different anesthetic techniques, and evaluating hemodynamic stability in relation to anesthetic depth.

The results of this study may contribute to a better understanding of eMAC and its potential role in clinical anesthesia practice.

Conditions

  • General Anesthesia
  • Intraoperative Monitoring
  • Anesthetic Depth

Interventions

DRUG

Sevoflurane + Remifentanil

Combination of an inhalational anesthetic (sevoflurane) and an intravenous opioid analgesic (remifentanil), both routinely used in clinical practice for maintenance of general anesthesia. These agents are administered according to standard of care, not as experimental interventions.

DRUG

Sevoflurane + Propofol + Remifentanil

Combination of an inhalational anesthetic (sevoflurane), an intravenous anesthetic (propofol), and an intravenous opioid analgesic (remifentanil). These agents are routinely used together in clinical practice for combined intravenous-inhalational anesthesia (CIVIA). All drugs are administered according to standard of care, not as experimental interventions.

Sponsors & Collaborators

  • Sakarya University

    lead OTHER

Principal Investigators

  • Ayca Tas Tuna, Professor, M.D. · Sakarya University Faculty of Medicine

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-11-01
Primary Completion
2026-01-15
Completion
2026-01-15

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07197567 on ClinicalTrials.gov