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Impact of Chronic and Acute Caffeine Intake on the Hematopoietic System

NCT07193264 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2025-09-29

No results posted yet for this study

Summary

This study investigates how caffeine intake affects blood stem and progenitor cells in healthy adults.

The trial will compare people who regularly consume caffeine with those who consume very little or none. All participants will receive a single 200 mg caffeine tablet (similar to one cup of coffee) under fasting conditions. Blood samples will be collected before and three hours after caffeine intake.

The study will assess whether caffeine influences the mobilization of blood stem and progenitor cells from the bone marrow into the bloodstream. It will also examine the effects of caffeine on the function, gene activity, and metabolism of blood cells.

Conditions

  • Healthy Adults; Hematopoietic System; Caffeine

Interventions

OTHER

Caffeine (200 mg)

Participants receive a single oral dose of 200 mg caffeine under fasting conditions. Blood samples are collected before and three hours after intake to evaluate effects on hematopoietic stem and progenitor cells, including mobilization, function, gene expression, and metabolism.

Sponsors & Collaborators

  • ETH Zurich

    collaborator OTHER

  • Laboratory of Stem Cell Biology and Ageing, ETH Zurich, Prof. Nina Cabezas-Wallscheid

    collaborator UNKNOWN

  • Prof. Dr. Nina Cabezas-Wallscheid, ETH Zurich

    collaborator UNKNOWN

  • Jasmin Rettkowski

    lead OTHER

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-10-31
Primary Completion
2027-12-31
Completion
2028-06-30

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07193264 on ClinicalTrials.gov