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Does Caffeine Facilitate Human Reward Learning Behaviors?

NCT05325502 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2026-03-17

No results posted yet for this study

Summary

"Learning from the rewards" is underlying the formulation of knowledge and habits in daily life. Caffeine is the most commonly used "psychoactive" substance that could change one's mind state by affecting the brain and nervous system. By such effects, caffeine enhances reward signals - dopamine - in human brains. In this research study, we will find out whether taking caffeine acutely or daily can enhance reward learning processes.

Conditions

  • Caffeine

Interventions

DIETARY_SUPPLEMENT

caffeine

two doses per day: 200 mg caffeine in the morning; 100 mg caffeine in the afternoon

DIETARY_SUPPLEMENT

mannitol

two doses per day: 200 mg in the morning \& 100 mg in the afternoon

Sponsors & Collaborators

  • Yu-Shiuan Lin

    lead OTHER

Principal Investigators

  • Yu-Shiuan Lin, PhD · Centre for Chronobiology, University Psychiatric Clinics Basel

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-05-05
Primary Completion
2025-12-31
Completion
2026-12-31

Countries

  • Switzerland

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05325502 on ClinicalTrials.gov