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Oral Bioavailability of the Phenolic Compounds in a Melissa Supplement

NCT06949592 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2025-06-15

No results posted yet for this study

Summary

The objective of this study is to identify phenolic compound biomarkers of the intake of a mixture of Melissa officinalis extract, acerola extract and vitamin B5. This will be done through the study of their bioavailability and nutrikinetics by measuring their plasma concentrations and urinary excretion over 24h by means of high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS). The study follows a cross-over, double-blind, randomized and placebo control design on 10 healthy subjects

Conditions

  • Nutrition, Healthy

Interventions

DIETARY_SUPPLEMENT

Placebo

Intake of 400 mg placebo (maltodextrin; encapsulated) in the morning (09:00)

DIETARY_SUPPLEMENT

M_ML

Intake of 400 mg M\_ML (encapsulated) in the morning (09:00)

DIETARY_SUPPLEMENT

M_ML

Intake of 400 mg M\_ML (encapsulated) in the evening (19:00)

Sponsors & Collaborators

  • Fytexia

    lead INDUSTRY

Principal Investigators

  • Antoni Caimari Palou, PhD · Fundació Eurecat

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-04-30
Primary Completion
2025-06-12
Completion
2025-06-12

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06949592 on ClinicalTrials.gov