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The Effect of Er,Cr:YSGG Laser-assisted Topical Anesthetic on Oral Mucosal Anesthesia

NCT07169032 · Status: COMPLETED · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2025-12-04

Study results available
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Summary

This study tests whether using an Er,Cr:YSGG laser before applying numbing gel (lidocaine) can help reduce pain during dental procedures compared to traditional methods. Investigators want to know:

Does the laser make the numbing gel work better and longer?

Does it lower pain and keep patients calmer (measured by heart rate)?

Investigators enrolled 20 adults (10 men, 10 women) and assigned them to three groups:

Laser + Numbing Gel: Laser was used on the gums before applying lidocaine.

Sham Laser + Numbing Gel: A fake laser was used with lidocaine.

Sham Laser + Vaseline: A fake laser was used with Vaseline (no numbing effect).

Participants reported pain levels on a scale (0=no pain, 10=worst pain) when a tiny needle touched their gums. Investigators also checked their heart rate.

Conditions

  • Anesthesia

Interventions

DEVICE

Er,Cr:YSGG laser irradiation

irradiation with a 2780 nm, 1.0 W Er,Cr:YSGG laser for 1 minute

DRUG

Sham Laser irradiation

sham laser irradiation for 1 minute

DRUG

Lidocaine

2% lidocaine gel

DRUG

Vaseline

Vaseline

Sponsors & Collaborators

  • Li Zhen Zhong

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-01-01
Primary Completion
2024-02-20
Completion
2024-02-21
FDA Drug
Yes
FDA Device
Yes

Countries

  • China

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07169032 on ClinicalTrials.gov