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Microneedle Pretreatment as a Strategy to Improve the Effectiveness of Topical Anesthetics Formulations

NCT05267938 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2022-03-21

No results posted yet for this study

Summary

A randomized, crossover, double-blind, two-sessions clinical trial with 30 male volunteers was performed to access pain of local anesthesia after using a topical anesthetic associated or not with prior application of microneedles to the palatal mucosa region

Conditions

  • Oral Cavity Disease

Interventions

DRUG

Topical Anesthetic

The topical anesthetic used in this experimental is EMLA® after the pre-treatment of the palatal mucosa

DRUG

Local anesthetic

After the pre-treatment with microneedles and the use of topical anesthetic, the needle and injection of local anesthetic was inserted and pain was evaluated

Sponsors & Collaborators

  • Texas Tech University

    collaborator OTHER

  • University of Campinas, Brazil

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-08-01
Primary Completion
2019-10-30
Completion
2020-01-30

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05267938 on ClinicalTrials.gov