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Effect of ORI-guided Oxygen Titration on Oxidative Stress in Rhinoplasty Surgery

NCT07158073 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2025-09-08

No results posted yet for this study

Summary

The aim of this study is to evaluate whether the use of Oxygen Reserve Index (ORİ) can prevent hyperoxia in patients undergoing rhinoplasty surgery and whether it can reduce oxidative stress caused by hyperoxia.

Conditions

  • Rhinoplasty
  • Oxidative Stress
  • Hyperoxia
  • Oxygen Reserve Index

Interventions

DEVICE

FiO₂ titration, under the guidance of ORI

In Group R, FiO₂ was titrated between 30% and 50% under the guidance of ORI and SpO₂ values. Accordingly, if SpO₂ was ≥ 98%, FiO₂ was reduced in 5% increments to a minimum of 30%, aiming to achieve an ORI value of 0 or as close to 0 as possible.

DEVICE

Conventional oxygen administration

In Group C, FiO₂ was maintained at 50% throughout the surgery, provided that SpO₂ remained ≥ 98%.

Sponsors & Collaborators

  • Dr. Lutfi Kirdar Kartal Training and Research Hospital

    lead OTHER_GOV

Principal Investigators

  • Banu E Çevik, MD · University of Health Sciences, Kartal Dr. Lütfi Kırdar City Hospital

  • Fatih D Geyik, MD · University of Health Sciences, Kartal Dr. Lütfi Kırdar City Hospital

  • Kemal T Saraçoğlu, MD · University of Health Sciences, Kartal Dr. Lütfi Kırdar City Hospital

  • Recep karakaşoğlu, MD · University of Health Sciences, Kartal Dr. Lütfi Kırdar City Hospital

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-03-01
Primary Completion
2021-08-20
Completion
2021-08-30

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07158073 on ClinicalTrials.gov