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Comparing Delayed vs Primary Wound Closure After Emergency Laparotomy: Impact on Infection, Healing, and Hospital Stay

NCT07142395 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 82

Last updated 2025-09-05

No results posted yet for this study

Summary

The purpose of this study is to find out which type of wound closure after emergency abdominal surgery leads to fewer wound infections and better recovery: closing the wound immediately after surgery (called primary closure) or waiting a few days before closing the skin (called delayed primary closure).

Wound infection is a common problem after emergency abdominal surgery (also called laparotomy). Some surgeons close the skin right away, while others wait a few days to reduce the risk of infection.

This study will help find out which method is better.

The main questions the study aims to answer are:

1. . Does delayed primary closure lower the rate of wound infection compared to primary closure?
2. . Does the wound open up (wound dehiscence) less often with delayed closure?
3. . Does delayed closure affect the length of hospital stay?

In this clinical trial:

* Adult patients needing emergency abdominal surgery will be included.
* Half the patients will have their wounds closed immediately (primary closure), and half will have delayed closure after 3-5 days of daily dressing.
* All surgeries will be done by experienced surgeons using the same technique.
* Patients will be followed for 4 weeks after surgery to monitor wound infection, wound opening, and length of hospital stay.

The results will help doctors choose the safest and most effective way to close surgical wounds after emergency abdominal surgery.

Conditions

  • Laparotomy Closure After Abdominal Surgery

Interventions

PROCEDURE

Immediate skin closure

After laparotomy wounds will be closed primarily using no. 1 vicryl suture

PROCEDURE

Delayed primary closure

Deeper layers of wound will be closed after surgery and loose mattress sutures will be applied to skin with prolene. After three to five days of daily dressing with bactericidal solution, the skin will be closed

Sponsors & Collaborators

  • Bkahtawar Amin Medical and Dental College Multan

    lead OTHER

Principal Investigators

  • Amjad A Professor, FRCS · Bakhtawar Amin Medical and Dental College

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-05-16
Primary Completion
2025-08-15
Completion
2025-08-15

Countries

  • Pakistan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07142395 on ClinicalTrials.gov