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Immune Dynamics in the Natural History of Chronic HBV Infection

NCT07137247 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 5000

Last updated 2025-09-30

No results posted yet for this study

Summary

The purpose of this observational study is to follow up on chronic HBV-infected patients over a long period of time to understand the changes in the immune status as age increases and the natural history of chronic HBV infection progresses. The main questions it aims to answer are:

* Does the natural history of chronic HBV infection progress with changes in HBV-specific immunity?
* What is the role of age in the natural history of chronic HBV infection?

Patients with chronic HBV infection who are untreated and aged 1-80 years will be followed up every six months. During each follow-up, HBV-related serological and virological indicators will be tested. Peripheral blood samples will also be collected to test HBV-specific immunity and the immune environment.

Conditions

  • HBV (Hepatitis B Virus)
  • HBV Infection
  • Chronic Hep B

Interventions

PROCEDURE

Venipuncture

For adults (including those who are 18 years old): During the routine follow-up visits, an extra 30 milliliters of peripheral blood will be drawn. For minors (under 18 years old): During the routine follow-up visits, an extra 6 milliliters of peripheral blood will be drawn. Follow-ups will be conducted every six months, with a minimum of six visit points.

Sponsors & Collaborators

  • Nanfang Hospital, Southern Medical University

    lead OTHER

Eligibility

Min Age
1 Year
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-02-01
Primary Completion
2040-12-01
Completion
2041-12-01

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07137247 on ClinicalTrials.gov