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Serum HBV RNA Value on Chronic Hepatitis B Virus Infection Manage

NCT03909191 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 454

Last updated 2021-02-02

No results posted yet for this study

Summary

As an alternative biomarker of intrahepatic covalently closed circular DNA(cccDNA) transcriptional activity, hepatitis B virus(HBV)RNA may evolve during long-lasting virus-host interactionsduring chronic hepatitis B viral infection.The distribution pattern of serum HBV RNA levels in the natural course of chronic HBV infection remains unclear. Furthermore,serum HBV RNA was associated with response to NAs. So it may be another clinical surrogate marker for intrahepatic cccDNA level after long-term NAs treatment and be used to monitor NAs therapy. The aim of this study was to evaluate thelevels of HBV RNA during the natural courseof CHB and the role in distinguishingthe natural phases of HBV infection and to investigate whether serum HBV RNA level at the end of long-term NAs treatment had a similar or better predict effect on off-therapy relapse than serum HBsAg titer.

Conditions

  • Chronic HBV Infection
  • Drug Withdrawal

Interventions

DIAGNOSTIC_TEST

serum HBV RNA

serum HBV RNA level was determined by using HBV-SAT kit at different time point

Sponsors & Collaborators

  • Changhai Hospital

    lead OTHER

Principal Investigators

  • Xuesong Liang, Dr · Changhai Hospital

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-02-01
Primary Completion
2020-05-01
Completion
2020-05-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03909191 on ClinicalTrials.gov