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HEARTS Trial for Thoracic Cancers

NCT07132918 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-03-11

No results posted yet for this study

Summary

The goal of this clinical trial is to compare a new way of using magnetic resonance-guided adaptive radiation therapy (MRgART) to the standard of care linear accelerator (LINAC) radiation treatment in people with cancer in the thoracic region near the heart.

The main question it aims to answer is whether MRgART affects the heart differently than LINAC.

Participants will:

* Receive radiation therapy
* Undergo MRIs and bloodwork
* Complete quality of life questionnaires

Conditions

  • Non-Small Cell Lung Cancer (Stage III)
  • Esophageal Cancer Stage I-III
  • Esophagogastric Cancer Stage I-III
  • Thymoma and Thymic Carcinoma Stage II-III
  • Other Cancers in the Thoracic Region

Interventions

RADIATION

MRgART

Magnetic Resonance-guided Adaptive Radiation Therapy (MRgART) is a form of MRgRT that incorporates daily adaptive planning, or making a new treatment plan each treatment, and real-time imaging during treatment delivery.

RADIATION

LINAC

Daily 3D x-ray scans will be obtained for radiation delivery to confirm tumor and organ at risk placement.

Sponsors & Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • University of Wisconsin, Madison

    lead OTHER

Principal Investigators

  • Carri Glide-Hurst, PhD, DABR, FAAPM · University of Wisconsin, Madison

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-10-08
Primary Completion
2029-03-31
Completion
2029-03-31
FDA Device
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07132918 on ClinicalTrials.gov