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Radiation Induced Cardiopulmonary Injury in Humans

NCT02259452 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 91

Last updated 2020-02-26

No results posted yet for this study

Summary

The purpose of the study is to assess the time, dose dependence, and fraction-size dependence of radiation (RT)-induced changes in regional lung and heart perfusion/function/structure following thoracic RT delivered using newer IMRT/conformal/radiosurgery techniques. The PI hopes to develop models to better relate and predict RT-induced changes in regional lung and heart perfusion/function/structure with changes in global cardiopulmonary function. Patients will undergo pre- and serial post-RT lung and heart assessments to better understand RT-induced regional heart/lung changes.

Conditions

  • Thoracic
  • Pulmonary Injury
  • Heart Injuries

Interventions

PROCEDURE

SPECT Lung Perfusion Scan

PROCEDURE

SPECT Heart Perfusion Scan

PROCEDURE

Pulmonary Function Tests

Sponsors & Collaborators

  • UNC Lineberger Comprehensive Cancer Center

    lead OTHER

Principal Investigators

  • Kyle Wang, MD · University of North Carolina at Chapel Hill, Department of Radiation Oncology

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-06-30
Primary Completion
2018-04-13

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02259452 on ClinicalTrials.gov