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Radiation-induced Cardiac Toxicity After Non-small Cell Lung Cancer Radiotherapy

NCT04867564 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2021-07-23

No results posted yet for this study

Summary

Despite the growing interest in investigating how the radiotherapy (RT) dose to anatomical substructures of the heart links to survival, the heart substructures at risk remain poorly defined. They are not delineated routinely as part of the RT planning process and there is no consensus on their dose constrains. With improving prognosis for non-small cell lung cancer (NSCLC) patients, the evidence relating irradiation of the heart to excess mortality has begun to accumulate.

The study aims to evaluate subclinical cardiac dysfunction in consecutive NSCLC patients treated with definitive RT and to investigate the predictive value of the heart substructures dosimetric parameters for subclinical and overt cardiac toxicity as assessed using traditional and speckle tracking echocardiography (STE). The study will also investigate whether subclinical alterations detected by echocardiography with strain imaging may serve as a marker for future clinical dysfunctions.

Conditions

Interventions

DIAGNOSTIC_TEST

Echocardiography

Traditional echocardiography and speckle tracking echocardiography (STE) before and 1, 6, and 12 months after RT

Sponsors & Collaborators

  • Military Institute od Medicine National Research Institute

    lead OTHER

Principal Investigators

  • Joanna Socha, MD, PhD · Military Institute od Medicine National Research Institute

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-05-01
Primary Completion
2024-05-01
Completion
2024-05-01

Countries

  • Poland

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04867564 on ClinicalTrials.gov